Sodium fluoride 의 作用機轉에 對한 硏究

초록

To investigate the acting mechanism of sodium fluoride on the blood pressure, the inotropic effect of isolated auricle and the tonicity of isolated intestine of rabbit, the author observed the catecholamine contents of cardiac muscle of rats after perfusion of Lock-Ringer solution containing various dose of sodium fluoride, and the influence of β-adrenergic blocking agent or the other drugs on the pressure response, the positive inotropic effect of isolated auricle and increased tonicity of isolated rabbit intestine induced by sodium fluoride. The results obtained were follows: 1. Large dose of sodium fluoride stimulated the release of catecholamine from the isolated perfused rat heart. 2. Large dose of sodium fluoride increased the amplitude of isolated rabbit auricle, which augmented effect is decreased by pretreatment of DCI or inderal. 3. Large dose of sodium fluoride rised blood pressure of rabbits, which effect is decreased by the pretreatment of DCI or isoproterenol. 4. The tonicity of isolated rabbit intestine is continuously increased by sodium fluoride, which effect is antagonized by DCI. atropine or papaverine.