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Directional and trans-endothelial migration of mesenchymal stem cell towards SDF-1a gradient on a microfluidic device
- Park Siwan;
- Jang, Hwan seok;
- Jeong, Gi Seok;
- Kim, Byung Soo;
- Park, Yong doo
Citations
SCOPUS
0초록
Homing of mesenchymal stem cell (MSC) for tissue regeneration is known to be controlled by a homing factor, stromal cell-derived factor 1α (SDF-1α) gradient released from injury site. Binding of SDF-1α leads to MSC's extravasation and migration towards the infarcted tissue. In this study, a microfluidic device was designed to witness the homing process of MSC towards SDF-1α gradient. SDF-1 antagonist AMD3100 blocked the binding of SDF-1α to the MSC's receptor which led to loss of directional migration. On the other hand, Rock inhibitor, Y-27632 and Rac inhibitor, NSC23766 had no effects on directional migration but decreased MSC's migration distance.
키워드
Collagen scaffold; Directional migration; EC; Extravasation; Microfluidics; MSC; SDF-1α; Bins; Cell culture; Fluidic devices; Stem cells; Tissue; Tissue regeneration; Collagen scaffolds; Directional migration; Endothelial migrations; Extravasation; Mesenchymal stem cell; Micro-fluidic devices; Migration distance; ROCK inhibitors; Microfluidics
- 제목
- Directional and trans-endothelial migration of mesenchymal stem cell towards SDF-1a gradient on a microfluidic device
- 저자
- Park Siwan; Jang, Hwan seok; Jeong, Gi Seok; Kim, Byung Soo; Park, Yong doo
- 발행일
- 2016-07
- 유형
- Conference Paper
- 저널명
- 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
- 페이지
- 453 ~ 454
- 언어
- ENG
- 출판사
- Chemical and Biological Microsystems Society
- 분량
- 2 페이지
- ISSN
- P 0000-0000