Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA-G levels and the disease: a meta-analysis

초록

Objective To investigate the association between HLA-G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA-G (sHLA-G) levels and SLE. Methods A meta-analysis was performed to investigate the relationships between HLA-G 14-bp insertion (I)/deletion (D), +3142 & x202f;G/C, +3035 & x202f;T/C, and +3003 & x202f;C/T polymorphisms and SLE as well as the relationship between sHLA-G serum/plasma levels in SLE patients and controls. Results Eleven publications fulfilled our inclusion criteria. Meta-analysis under the dominant model showed an association in the overall group between the II+ID genotype of HLA-G 14-bp I/D polymorphism and SLE (OR & x202f;= 1.213, 95%CI & x202f;= 1.077-1.365, P & x202f;= 0.001). Ethnicity-specific meta-analysis showed an association between II+ID and SLE in Asians but not in South American and European populations. No correlation was observed using the allele contrast between HLA-G +3142 & x202f;G/C polymorphisms and SLE. Contrastingly, +3035 & x202f;T/C and +3003 & x202f;C/T meta-analysis showed a significant allelic association between SLE and HLA-G polymorphisms (OR & x202f;= 1.378, 95%CI & x202f;= 1.109-1.713, P & x202f;= 0.004; OR & x202f;= 1.834, 95%CI & x202f;= 1.112-3.022, P & x202f;= 0.017; respectively). sHLA-G levels were significantly higher in the SLE group than in the controls (SMD & x202f;= 0.637, 95%CI & x202f;= 0.382-0.892, P & x202f;< 0.001). Conclusion We showed association of HLA-G 14-bp I/D, +3035 & x202f;T/C, and +3003 & x202f;C/T polymorphisms with SLE susceptibility and significantly higher circulating sHLA-G levels in SLE patients.

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