Salmonella typhimurium with gamma-radiation induced H(2)AX phosphorylation and apoptosis in melanoma

초록

To investigate the combinatorial effects using Salmonella and gamma-radiation, the Salmonella typhimurium infection in combination with gamma-radiation was investigated on melanoma. We showed that ROS expression and H(2)AX phosphorylation increased during stress by gamma-radiation irrespective of Salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. In addition, tumor growth was suppressed by this combinatory therapy suggesting candidates for radiation therapy against melanoma.

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