A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Ryu J.Y.; Lee S.H.; Lee E.J.; Min K.H.; Hur G.Y.; Lee S.Y.; Kim J.H.; Lee S.Y.; Shin C.; Shim J.J.; In K.H.; Kang K.H.; Yoo S.H.

doi:10.4046/trd.2012.73.5.273

상세 보기

A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Ryu J.Y.;
Lee S.H.;
Lee E.J.;
Min K.H.;
Hur G.Y.;
... Lee S.Y.;
... Kim J.H.;
... Lee S.Y.;
... Shin C.;
... Shim J.J.;
... In K.H.;
... Kang K.H.;
외 1명

Citations

SCOPUS

9

초록

Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright©2012. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

키워드

Limbic encephalitis; Lung neoplasms; Paraneoplastic syndromes; aciclovir; antineoplastic agent; oxcarbazepine; phenytoin; valproic acid; aged; amygdaloid nucleus; article; case report; cerebrospinal fluid; computer assisted emission tomography; disease association; disorientation; electrocardiogram; follow up; herpes simplex encephalitis; hippocampus; human; human tissue; laboratory test; lung small cell cancer; male; neuroimaging; neurologic examination; nuclear magnetic resonance imaging; paraneoplastic neuropathy; pleura effusion; seizure; thorax radiography

제목: A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

저자: Ryu J.Y.; Lee S.H.; Lee E.J.; Min K.H.; Hur G.Y.; Lee S.Y.; Kim J.H.; Lee S.Y.; Shin C.; Shim J.J.; In K.H.; Kang K.H.; Yoo S.H.

DOI: 10.4046/trd.2012.73.5.273

발행일: 2012-11

유형: Article

저널명: Tuberculosis and Respiratory Diseases

권: 73

호: 5

페이지: 273 ~ 277

언어: ENG

출판사: 대한결핵및호흡기학회

발행국가: 대한민국

분량: 5 페이지

ISSN: E 2005-6184
P 1738-3536