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Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage
- Hyun, Young Eum;
- Kim, Hong-Rae;
- Choi, Yongseok;
- Jeong, Lak Shin
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14Citations
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13초록
A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and Ti-III-mediated regio- and stereoselective epoxide cleavage as key steps.
키워드
carbocyclic nucleoside; entecavir; hepatitis B; Stereoselective synthesis; titanium; VIRUS INFECTION; ASYMMETRIC EPOXIDATION; VERSATILE INTERMEDIATE; 2,3-EPOXY ALCOHOLS; BMS-200475; MECHANISM; KETONES; POTENT
- 제목
- Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage
- 저자
- Hyun, Young Eum; Kim, Hong-Rae; Choi, Yongseok; Jeong, Lak Shin
- 발행일
- 2017-09
- 유형
- Article
- 권
- 6
- 호
- 9
- 페이지
- 1213 ~ 1218
- 언어
- ENG
- 출판사
- Wiley - VCH Verlag GmbH & Co. KG
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- E 2193-5815
P 2193-5807