The validation of osteoporosis self-assessment tool for Asians using fracture probability according to BMI and age in Korean postmenopausal women : Ajou Bone Love Data

초록

Fracture probability in postmenopausal women depends on factors such as bone mineral density (BMD), body mass index (BMI), and age. The association of these factors with fracDownloaded from https://academic.oup.com/jbmr/article/38/S2/1545/7615083 by Korea University Library user on 22 November 2024 413 ASBMR 2023 Annual Meeting LB SUN-639 Sunday Orals tures has been reported; however, the association of fracture probability with BMI and age was not assessed concurrently. Therefore, we investigated fracture risk according to different BMI and age groups in postmenopausal women. Medical records of 22,142 women aged >=50 years who underwent BMD measurement between January 2006 and December 2014 at Ajou university hospital were checked for exclusion criteria that are known to interfere with normal bone metabolism, such as thyroid illness, rheumatoid arthritis, and prescription of hormone replacement treatment. Overall, 6,503 women with baseline BMD were included, and their fracture records after BMD measurements were identified. They were categorized into seven age groups of 5-year interval (50-54, 55-59, 60-64, 65-69, 70-74, 75-79, and >= 80 years) and five BMI groups according to the Korean Society for the Study of Obesity Guideline: underweight (BMI < 18.5), normal (18.5 <= BMI < 23), overweight (23 <= BMI < 25), Obese I (25 <= BMI < 30), and Obese II&III (BMI >= 30). Women in each age and BMI group were investigated for T-score distribution and fracture incidence. The distribution of BMD for normal, osteopenia, and osteoporosis was 28.4%, 45.5%, and 26.1%, respectively. Osteoporosis prevalence was 53%, 27.7%, 24.7%, 23.5%, and 20.2% for underweight, normal, overweight, obese I, and obese II & III, respectively. Fracture rates were 10.3%, 6.3%, 7.2%, 8.4%, and 7.4% for underweight, normal, overweight, obese I, and obese II & III, respectively. Regardless of BMI, osteoporosis increased significantly with advancing age; however, fracture risk significantly increased only in women aged >=70 years (Table 1). Fracture risk did not follow the trend of osteoporosis when age and BMI were considered together. Underweight women were at increased risk of fracture from age 65 years. However, belonging to BMI groups other than underweight did not significantly increase fracture risk in older women, irrespective of BMD.