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No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients
- Kang, Seung-Gul;
- Choi, Jung-Eun;
- An, Hyonggin;
- Lim, Se-Won;
- Lee, Heon-Jeong;
- ... Han, Changsu;
- ... Kim, Yong-Ku;
- ... Kim, Seung-Hyun;
- ... Lee, Min-Soo;
- ... Joe, Sook-Haeng;
- ... Jung, In-Kwa;
- ... Kim, Leen;
- 외 1명
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21초록
Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (chi(2)=2.37, p=0.306) and alleles (chi(2)=0.03. p=0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.
키워드
- 제목
- No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients
- 저자
- Kang, Seung-Gul; Choi, Jung-Eun; An, Hyonggin; Lim, Se-Won; Lee, Heon-Jeong; Han, Changsu; Kim, Yong-Ku; Kim, Seung-Hyun; Cho, Sung Nam; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa; Kim, Leen
- 발행일
- 2008-08-01
- 유형
- Review
- 권
- 32
- 호
- 6
- 페이지
- 1545 ~ 1548
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1878-4216
P 0278-5846