좌골신경주사손상에 대한 실험적 연구 - 제1보 : 병리조직학 -

초록

Sciatic nerve injury can result from intragluteal administration of any kind of antibictics or other agents therapeutically or prophylactically. This experimetal study was conducted in order to observe the histopathological findings of injured sciatic nerve following injection with normal saline, chloromycetin, penicillin and rheumapyrine. Fifty-five experimental normal adult rabbits were divided into 4 groups and various substances were injected intraneurally on the right side and perineurally on the lelt side. Pathological specimenes were then taken at intervals of 1, 3, 7, and 21 days after injection. The results obtained were summerized as follows: 1. Rheumapyrine produced the greatest reaction, penicllin was the next and chlomycetin was the least damaging of the drugs in this study. 2. More corspicuous pathological changes were observed on the right side than on the left side. 3. It was thought that major source of damage to the sciatic nerve was chemical toxicity to the peripheral nerve. 4. Intraneural injectione of rheumapyrine induced irreversible damage on nervous tissue andperineural fibrosis. 5. Intraneural injection of penicillin caused transient reversible damage on nervous tissue with perineural deposition of collagen. 6. Intraneural injection of chloromycetin induced early reversible damage on nervous tissue with persistart inflammatory reaction in soft tissue. 7. Perizeural injecticn of rheumapyrine, penicillin and chloromycetin induced mild damage on nervors tissue and revealed moderate inflammatory reaction on soft t'ssue.