17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

Bang, Sang Soo; Yoo, S.; Yang, T. J.; Cho, H.; Hwang, S. W.

doi:10.1111/j.1476-5381.2011.01568.x

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17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

Bang, Sang Soo;
Yoo, S.;
Yang, T. J.;
Cho, H.;
Hwang, S. W.

Citations

WEB OF SCIENCE

119

Citations

SCOPUS

133

초록

BACKGROUND AND PURPOSE Transient receptor potential ion channel vanilloid 3 (TRPV3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. The presence of TRPV3 inhibitors would improve our understanding of TRPV3 function and help to develop receptor-specific analgesics. However, little is known about physiological substances that specifically inhibit TRPV3 activity. Here, we investigated whether 17(R)-resolvin D1 (17R-RvD1), a naturally occurring pro-resolving lipid specifically affects TRPV3 activity.

키워드

17(R)-resolvin D1; TRPV3; specific inhibitor; pain; keratinocytes; nociceptive behaviours; inflammation; RESOLVIN D1; CAPSAICIN RECEPTOR; INFLAMMATORY HYPERALGESIA; MECHANICAL HYPERALGESIA; NOCICEPTIVE NEURONS; SENSORY NEURONS; PAIN; ACTIVATION; TRPV3; BRADYKININ

제목: 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

저자: Bang, Sang Soo; Yoo, S.; Yang, T. J.; Cho, H.; Hwang, S. W.

DOI: 10.1111/j.1476-5381.2011.01568.x

발행일: 2012-02

유형: Article

저널명: British Journal of Pharmacology

권: 165

호: 3

페이지: 683 ~ 692

언어: ENG

출판사: Wiley-Blackwell

발행국가: 미국

분량: 10 페이지

ISSN: E 1476-5381
P 0007-1188