Associations Between Interleukin-10 Polymorphisms and Susceptibility to Sjögren's Syndrome: A Meta-Analysis

초록

This study sought to investigate the association between interleukin-10 (IL10) polymorphisms and susceptibility to Sj & ouml;gren's syndrome. A systematic search of the Medline, Embase and Web of Science databases was conducted to identify relevant articles from inception to April 2024. No restrictions were placed on race, ethnicity or geographic area, but only studies published in English were included. A meta-analysis was conducted to evaluate the association among the IL10-1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms, as well as their haplotypes and the risk of developing Sj & ouml;gren's syndrome. The included studies involved 998 Sj & ouml;gren's syndrome patients and 1576 controls. Ten studies were included in the meta-analysis. Meta-analysis of the IL10-1082 G/A polymorphism revealed no significant association with Sj & ouml;gren's syndrome (odds ratio [OR] = 1.115, 95% confidence interval [CI]: 0.888-1.401, p = 0.343), with stratification by ethnicity yielding consistent results for Europeans and Latin Americans. Similarly, the IL10-819 C/T polymorphism was not associated with Sj & ouml;gren's syndrome in any study subjects (OR = 0.859, 95% CI: 0.648-1.138, p = 0.290). The IL10-592 C allele also exhibited no association with Sj & ouml;gren's syndrome (OR = 1.131, 95% CI: 0.776-1.646, p = 0.522). However, the GCC carrier status demonstrated a significant association with Sj & ouml;gren's syndrome across all study subjects (OR = 1.496, 95% CI: 1.200-1.865, p < 0.001), particularly in Europeans (OR = 1.444, 95% CI: 1.085-1.921, p = 0.012) and Latin Americans (OR = 1.324, 95% CI: 1.115-2.366, p = 0.012). A significant protective effect of the homozygous ATA/ATA haplotype on Sj & ouml;gren's syndrome was found in Europeans (OR = 0.320, 95% CI: 0.121-0.846, p = 0.022).

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