Expression and Distribution of the Na+：HCO3- Cotransporter(NBC) and K+：Cl- Cotransporter(KCC) mRNA in Human Nasal Mucosa and Nasal Polyp

초록

Background and Objectives：Electrolyte transport by nasal epithelia has ben sugested to be important for controlling the transport of ion and water in various fluid-transporting epithelia is strictly dependent on the localization of specific membrane proteins in the polarized epithelial cells. Na+： HCO3-cotransporter (NBC) transports Na+ and HCO3- into the intracellular from extracellular space and induces the evacuation of H+ , regulating pH. K+： Cl- cotransporter (KCC) controls the cel the presense of mRNA for NBC and KC in human inferior turbinate and nasal polyp. Materials and Method：The expres-sion of NBC and KC mRNA isoforms in inferior turbinate mucosa and nasal polyp was evaluated, using RT-PCR and in situ hybridization. Results：RT-PCR revealed that the inferior turbinate and nasal polyp mucosa expressed kNBC, KC1 and 4 mRNA. In in situ hybridization, their distribution was noted in the epithelial layer and submucosal glands of both mucosa. Conclusion：controling the fluid and ion transport in nasal epithelium and submucosal glands.

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