Volume replacement correlates with breast-conserving surgery and adjuvant radiotherapy using liquid-type acellular dermal matrices in early-stage breast cancer

초록

Background: Although the incidence of breast cancer is steadily increasing, mortality rates have decreased significantly due to early diagnosis and improved treatment outcomes. Several reconstructive techniques have been developed to compensate for the loss of breast shape and volume after mastectomy, and reconstruction with acellular dermal matrices (ADMs) using extracellular matrix has received increasing attention. This study aimed to evaluate whether liquid-type ADMs can enhance volume replacement in patients who have undergone radiation therapy after breast-conserving surgery. Materials and Methods: This was a retrospective study of 349 patients with early-stage breast cancer who underwent breast conservation surgery and radiation therapy, 17 of whom used liquidtype ADM during surgery, and the changes in breast volume before and after radiation therapy were measured using a radiation treatment planning tool. Statistical analysis and matching techniques were used to compare the results between the control and experimental groups. Results: No statistically significant difference in post-radiation breast volume retention between the experimental and control groups was observed. However, the experimental group using ADM had a slightly higher volume retention rate than the control group: the control group had a mean volume loss of 99.702%, while the experimental group had a mean volume gain of 101.926%. Conclusion: The effectiveness of liquid-type ADM in maintaining breast volume in patients who received radiation therapy after breast-conserving surgery was not statistically significant. However, volume increased in the experimental group, suggesting that ADM may positively affect breast reconstruction. No conflict of interest