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Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization
- Lee J.;
- Wang J.;
- Torbenson M.;
- Lu Y.;
- Liu Q.Z.;
- 외 1명
Citations
SCOPUS
17초록
We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.
키워드
actin; cytokeratin; desmin; neurofibromin; smooth muscle actin; succinate dehydrogenase; succinate dehydrogenase subunit B; unclassified drug; vimentin; adult; article; cancer grading; case report; chromosome 10p; chromosome 1q; chromosome 5p; chromosome loss; comparative genomic hybridization; cystosarcoma phylloides; female; gene loss; gene mapping; genetic association; histopathology; human; human cell; human tissue; mastectomy; melanoma; needle biopsy; priority journal; spindle cell carcinoma; tumor suppressor gene; tumor volume; Breast Neoplasms; Chromosome Mapping; Female; Genes, Neurofibromatosis 1; Humans; Middle Aged; Neurofibromatosis 1; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phyllodes Tumor; Succinate Dehydrogenase; Phyllodes
- 제목
- Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization
- 저자
- Lee J.; Wang J.; Torbenson M.; Lu Y.; Liu Q.Z.; Li S.
- 발행일
- 2010
- 유형
- Article
- 권
- 196
- 호
- 2
- 페이지
- 179 ~ 183
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 미국
- 분량
- 5 페이지
- ISSN
- P 0165-4608