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Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents
- Naik, Siddhi D.;
- Chandra, Girish;
- Sahu, Pramod K.;
- Kim, Hong-Rae;
- Qu, Shuhao;
- 외 2명
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5초록
Stereo- and regio-selective synthesis of 3'-C-substituted-(N)-methanocarba adenosines 3a-c as potential anticancer agents was achieved by employing stereoselective cyclopropanation, stereoselective nucleophilic addition, regioselective isopropylidene cleavage and regioselective base condensation of cyclic sulfate as key steps.
키워드
STEREOSELECTIVE-SYNTHESIS; ANTITUMOR-ACTIVITY; ORGANIC-SYNTHESIS; CYCLIC SULFATES; SUGAR RING; NUCLEOSIDES; NUCLEOTIDES; 1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE; INHIBITORS; REDUCTASE
- 제목
- Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents
- 저자
- Naik, Siddhi D.; Chandra, Girish; Sahu, Pramod K.; Kim, Hong-Rae; Qu, Shuhao; Yoon, Ji-seong; Jeong, Lak Shin
- 발행일
- 2016-11
- 유형
- Article
- 권
- 3
- 호
- 11
- 페이지
- 1472 ~ 1480
- 언어
- ENG
- 출판사
- Royal Society of Chemistry
- 발행국가
- 영국
- 분량
- 9 페이지
- ISSN
- E 2052-4129
P 2052-4110