Transfusion-associated iron overload as a predictive factor for poor stem cell mobilization in patients with haematological malignancies

초록

Transfusion-associated iron overload is often observed in patients with haematological malignancies. We analysed the effect of iron overload, indicated by high serum ferritin level, on the mobilization of CD34+ peripheral blood stem cells (PBSCs). We evaluated the association between the serum ferritin level prior to PBSC collection and the number of CD34+ cells collected through leukapheresis in 51 patients with various haematological malignancies. Patients with serum ferritin level over 1000 ng mL-1 were defined as high-ferritin group. Comparing the good (≥1 × 10 6 per kg CD34+ cells) and poor (<1 × 10 6 per kg CD34+ cells) mobilizing groups, there was no difference in disease status, previous chemotherapies and white blood cell count at the first day of apheresis. However, there was a significant difference in the median units of red blood cell transfused between the good and poor mobilizer (2 vs. 8 units; P = 0.012). Serum ferritin level was notably higher in the poor mobilizer (1670 ± 1320 ng mL-1) compared with the good mobilizer (965 ± 705 ng mL-1, P = 0.035). The cumulative number of CD34+ cells per kg collected during the whole procedure was significantly lower in the high-ferritin group (5.5 ± 4.7 × 106 per kg vs. 13.1 ± 9.1 × 106 per kg, P = 0.01). Multivariate analysis revealed that serum ferritin level remained as an independent predictive factor for poor PBSC mobilization. Our study indicated that transfusion-associated iron overload is a predictive factor for poor PBSC mobilization. Iron chelation therapy prior to apheresis may be required to collect sufficient numbers of PBSCs in the iron overload patients. © 2008 The Authors.

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