A case of propylthiouracil induced diffuse pulmonary hemorrhage

Lee S.Y.; Jung J.Y.; Lee K.J.; Lee S.H.; Kim S.J.; Lee E.J.; Hur G.Y.; Jung H.C.; Lee S.Y.; Kim J.H.; Shin C.; Shim J.J.; In K.H.; Kang K.H.; Yoo S.H.

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A case of propylthiouracil induced diffuse pulmonary hemorrhage

Lee S.Y.;
Jung J.Y.;
Lee K.J.;
Lee S.H.;
Kim S.J.;
... Hur G.Y.;
... Kim J.H.;
... Shin C.;
... Shim J.J.;
... In K.H.;
... Kang K.H.;
... Yoo S.H.;
외 3명

Citations

SCOPUS

1

초록

Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

키워드

ANCA; Diffuse alveolar hemorrhage; Propylthiouracil; carbimazole; clozapine; hemosiderin; hydralazine; minocycline; myeloperoxidase; neutrophil cytoplasmic antibody; penicillamine; propylthiouracil; thiamazole; adult; ANCA associated vasculitis; article; case report; clinical feature; enzyme specificity; Graves disease; human; Korea; lung hemorrhage; lung lavage; male

제목: A case of propylthiouracil induced diffuse pulmonary hemorrhage

저자: Lee S.Y.; Jung J.Y.; Lee K.J.; Lee S.H.; Kim S.J.; Lee E.J.; Hur G.Y.; Jung H.C.; Lee S.Y.; Kim J.H.; Shin C.; Shim J.J.; In K.H.; Kang K.H.; Yoo S.H.

발행일: 2005

유형: Article

저널명: Tuberculosis and Respiratory Diseases

권: 58

호: 1

페이지: 78 ~ 82

언어: KOR

분량: 5 페이지

ISSN: P 0378-0066