Association between IL-6-174 G/C, IL-6-634 G/C, and IFN-gamma+874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis

초록

Objective The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models. Results A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133–1.734, p = 0.002), but not in Caucasians. Conclusions This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

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