Late Breaking Abstract - Association between dynamic expiratory tracheal collapse and obstructive sleep apnoea

초록

Background: Excessive dynamic tracheal collapse may occur from excessive inward bulging of the posterior membrane of the trachea during expiration. These have been associated with respiratory disorders, including COPD. The present study aimed to evaluate the association between the percentage of expiratory tracheal collapse (pETC) as measured on chest computed tomography (CT) and objectively measured obstructive sleep apnoea (OSA) severity. Methods: A total of 732 participants of the Korean Genome and Epidemiology Study, who underwent both chest CT and in-home polysomnography, were cross-sectionally analyzed. Participants were divided into three groups based on the severity of OSA: no OSA (apnoea-hyponoea index [AHI] <5), mild OSA (5 ≤AHI <15), and moderate-to-severe OSA (AHI ≥15). We analyzed the association between the pETC and the severity of OSA using multivariate linear regression models. Results: For the pETC, the difference in participants with moderate-severe OSA was 2.47% (P=0.01) as compared with no OSA. In addition, the association between moderate-severe OSA in women was slightly stronger than in those without OSA in women (β=3.27; P=0.03). There was also a trend significant of OSA severity on the pETC (Ptrend=0.006 in total participants; Ptrend=0.008 in women). Conclusion: We suggest that the severity of OSA in general population was independently associated with the increased expiratory tracheal collapse.