한탄바이러스에 대한 면역억제제 및 항혈액응고제의 작용

초록

ln 1976, Lee and Lee discovered the etiologic agent of Korean hemorrhagic fever (KHF), Hantaan virus, although similar diseases to KHF had been reported as hemorrhagic nephrosonephritis in Russia, as nephropathia epidemica in Scandinavia and epidemic hemorrhagic fever in China. In 1981, French et al. Reported a succesful growth of Hantaan virus in A 549 cells which originated from alveolar epithelial cells of a human lung cancer. The growth of Hantaan virus and the appearance of antigen-antibody complex in lung tissues of A-podemus agrarius following intramuscular inoculation of the virus and cyclophosphoamide (procytox) and also the effect of anticoagulants to infectivity of Hantaan virus in Apodemus agrarius were studied. The following results were obtained. After inoculation of Hantaan virus in Apodemus agrarius, the formation of immune complex was effectively suppressed by consecutive injection of procytox intramusculary per 3-6mg three times at certain intervals. 2. The effect of anticoagulants, EDTA, Heparin and Sod. Citrate to infectivity of Hantaan virus in Apademus agrarius was not demonstrated. Among these, EDTA was the most safe anticoagulant in Hantaan virus experiment.