흰쥐에서 급성출혈성 저혈압에 의한 적혈구 형태변화에 대한 Dexamethasone의 영향

초록

Normal resting form of the red cell is a biconcave disc. All of the factors which are necessary for the maintenance of this form are not understood, but variations in the shape and dimensions of the red cell can be useful in the differential diagnosis of anemias. The scanning electron microscope has a resolution of 200Å, or ten times that of the light microscope. In addition, it has a large depth of focus and presents a three dimensional view of red cells. These features having made it possible to denote the two forms of the normal red cell will serve to bring this concept into focus: "discocyte"-for the biconcave disc, the usual circulating form of the red cells-and "echinocyte" for the crenated, spiculed form produced by alterations in the inta-or extracellular enviroment. In this study, the auothers induced hypotension by acute hemorrhage, and compared percent appearance of echinocyte in the pretreated group with saline and pretreated group with dexamethasone under the scanning electron microscope. The results are as follows; Percent appearance of echinocyte before hemorrhage, in control group 1.82%, in experimental group 0,80% 30 minutes after hemorrhage, in control group 13.36%, in experimental group 3.43% 60 minutes after hemorrhage, in control group 17.55%, in experimental group 12.52% 90 minutes after hemorrhage, in control group 13.61%, in experimental group 12.50% 120 minutes after hemorrhage, in control group 11.09%, in experimental group 12.26% 150 minutes after hemorrhage, in control group 7.30%, in experimental group 9.85%

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