위선암에서 cyclin D1 발현의 의의

초록

Cell cycle progresses through the process of cyclin production and degradation in its specific phase and consequential phosphorylation of cyclin dependent Kinase(CDK) exists in all phases of the all cycle. Cancer cells have abnormal cell-cycle relating constituents, such as overexpression of cyclin. mutation or deletion of CDK-inhibitors and failures in feedback controls at checkpoints. The present study aims to assess the value of cyclin D1 expression to predict prognosis in patients with gastric adenocarcinoma. We evaluated cyclin D1 expression on 61 gastric adencarcinomas using the immunohistochemical staining and compared this with the survival and clinico-pathological parameters. Immunoreactivity for cyclin D1 protein was detected in 22 patients (36.1%). There were no significant correlations between the expression of cyclin D1 protein and age, sex, site, tumor invasion, tumor size, lymph node metastasis, distant metastasis, or stage except histologic type and differentiation (P=0.045). Survival curves revealed that there was no significant difference of the prognosis between patients with cyclin D1 expression and those without cyclin D1 expression(P=0.304). Immunohisto-chemical analysis of cyclin D1 might not be useful for evaluating the prognosis of patients with gastric adenocarcinoma.