Facial resurfacing in xeroderma pigmentosum with chemical peeling

초록

Xeroderma pigmentosum is an autosomal-recessive disease characterized by sensitivity to sunlight and the early appearance of multiple cutaneous tumors.(1) The dermatologic manifestation can be varied, but a high prevalence of skin cancers, basal and squamous cell carcinomas, malignant melanoma, and more rarely keratoacanthomas, angiomas, fibromas, and sarcomas are hallmarks of the disease, The clinical manifestations appear early in life, after the child is first exposed to the sun. Life expectancy is significantly reduced because of metastases, infection, or neurologic complications.(2) Despite the discovery of the genetically determined DNA defect in xeroderma pigmentosum,(3) there is no cure, and the outlook for patients with this disease remains bleak. Until now, the treatment modalities have been prophylaxis by avoidance of solar exposure, topical 5-fluorouracil, oral retinoids, surgical excision of premalignant and malignant tumors and resurfacing with skin grafts, and dermabrasion.(4) The rarity of xeroderma pigmentosum renders controlled trials of an! treatment modality impracticable, Any agent or modality that minimizes the background skin damage could greatly facilitate patient care.

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