백서에서 aspirin과 prostaglandin E1이 미세혈관 문합의 개존에 미치는 효과

초록

In the field of microsurgery, the vascular obstruction of the microvascular anastomosis by thrombus is one of the most important complication. The purpose of this study is to compare the effect between aspirin and prostaglandin E1(PGE1) which act as the peripheral vasodilatation and platelet disaggregation. We have used total 48 white male rats and divided them into three gruoups(A, B and C group). Each group consists of 16 rats respectively. A group is as control, B group is medicated with aspirin(3.0㎎/㎏/day) and C group with PGE1(1.2㎍/㎏/day). The gross and histopathologic findings at anastomosed site were observed on 3, 5, 10 and 15 days after vascular anastomosis and the results were obtained as the followings. 1. The microvascular patency rate is 81.2% in control group, 93.8% in aspirin group and 100% in PGE1 group. 2. On the histologic examination, the formation of mural thrombus is decreased both in the aspirin and PGE1 group as comparing with the control group and also the hypertrophy of the intima forming from media is less formed in PGE1 group than aspirin group and the degree of thickeness is also less. 3. The fibrosis of media is less observed in PGE1 group than aspirin group. According to the above results, the application of PGE1 to the microsurgery is considered to be effective on the prevention of the thrombus formation and on providing high patency rate.

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