Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects

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초록

Anti-Aβ antibodies are being developed as potential treatments for Alzheimer’s disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.

키워드

AMYLOID-BETA; ALZHEIMER-DISEASE; IMAGING ABNORMALITIES; MICE; DIAGNOSIS; MODEL
제목
Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects
저자
Roh, Jee Hoon; Holtzman, David M.
DOI
10.1016/j.neuron.2012.11.018
발행일
2012-02
저널명
Neuron
권
76
호
5
페이지
859 ~ 861

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