Interleukin-18/-607 gene polymorphism in allergic rhinitis

초록

Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

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