Genomic imbalances in Korean hepatocellular carcinoma

초록

Hepatocellular carcinoma (HCC) is one of the most prevalent gastrointestinal malignant tumors in Southeast Asia. Thirty-one cirrhotic HCC, 14 noncirrhotic HCC, and 13 metastastic HCC in the Korean population were investigated on microdissected tissues for chromosomal aberrations by degenerate oligonucleotide-primed polymerase chain reaction (PCR) comparative genomic hybridization. A number of prominent sites of genomic imbalances were observed. The gains of 1q, 6p, 7, 8q, 12q, 13q31similar toq32, 16p, 17q, and 20q and the losses of 1p, 4q, 6q, 8p, 9p, and 13q regions were observed with a similar high frequency in all types. Various chromosomal aberrations were observed preferentially to specific types. Gains of 4p15similar topter, 10q24similar toqter, 18pl1similar topter, and 19p10similar topter and a loss of 11q14similar toq22 were observed in the cirrhotic HCC, whereas losses of 14q21similar toq23 and 10q22similar toq23 were observed in noncirrhotic HCC. In metastatic HCC, gains of 3q25similar toqter and Xp21similar topter and losses of 21q11similar toqter and Y were observed. The recurrent gains and losses of chromosomal regions identified in this study are consistent with several previous observations and provide possible candidate regions for the involvement of tumorigenesis and progressions of HCC. (C) 2003 Elsevier Science Inc. All rights reserved.

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