Microfludics spinning of flat fiber with micro grooves for cell-aligning scaffolds

초록

In this study, we propose a method for continuously fabricating alginate flat microfibers with size tunable grooved microstructures using a microfluidic system. By introducing a sheath fluid with a high-speed flow rate, an alginate solution could be both flattened and polymerized simultaneously. Raised patterns could be engraved on the surfaces of the flat fibers in the longitudinal direction, with successful control over the number and dimensions of microscale-grooves via regulation of the slit-shaped channel.