Nocturia in obstructive sleep apnea

초록

Objectives:About half of obstructive sleep apnea (OSA) patients com-plain of nocturia. Despite this relevance, there is little published infor-mation about the predictive index of nocturia in patients with OSA.We investigated the prevalence of nocturia in patients with OSA andaimed to determine the possible predictive factors of nocturia in thesepatients.Methods:We included 1264 untreated patients with OSA (Apnea-Hypopnea Index, AHI≥5/h on polysomnography [PSG]) from January2017 to January 2020 and conducted retrospective cross-sectionalstudy. All patients underwent Beck Depression Inventory-II (BDI-II),Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI),and Epworth Sleepiness Scale. Patients were first classified accordingto gender, and then reclassified according to the presence of nocturia.Patients who responded that they had two or more urinations duringsleep were included in the nocturia group. In this study, we comparedclinical factors and sleep parameters of nocturia and non-nocturiagroup using thet-test or chi-square test.Results:Among OSA patients, 35.2% (337/958) of men and 59.8%(183/306) of women had nocturia. The nocturia group was older, hadhigher scores in the BDI-II, PSQI, and ISI, and had more underlying dis-eases regardless of sex. The AHI did not differ between the nocturiaand the non-nocturia group, however, 90% oxygen desaturation index(90% ODI) and wakefulness after sleep onset was higher and N3 sleepwas lesser in the nocturia group in male OSA patients. In the femalepatients, the comparison between the two groups was not significant.Results of multivariate logistic analysis showed that 90% ODI was anindependent risk factor of nocturia in male OSA patients.Conclusions:Our study suggested that nocturia might be associatedwith hypoxia and sleep quality in male OSA patients. And 90% ODI isa possible risk factor of nocturia among them