rhGM-CSF (Leucogen)의 비감염성 상처 치유 효과에 관한 연구

초록

Background: rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing on the uninfected wounds. Methods: Thirty Sprague-dawley white mice(250-300g) were selected in this study . The number of wound with the diameter of 5 mm, was 3 in left and 3 in right at the symmetric sites, respectively . The site of rhGM-CSF dressing was decided by a randomization. rhGM-CSF(Leucogen®) was diluted in the distilled water(5 µg/mL). The experimental wound group was dressed by l mL of distilled water mixed with rhGM-CSF and control wound group was dressed by l mL of distilled water. The dressing was done, every 24 hours. The criteria of comparison were the duration of wound healing duration, histologic findings and the bacterial culture of wound sites. Results: The duration of wound healing was 10.3±1.7 days in experimental group and 10.2±2.8 days in control group, without significant difference. There was no specific difference of histologic findings between both groups. The pathogen was not found, at all. Conclusion: It seems to be that rhGM-CSF has no prominent effect on the uninfected wound healing in the mice without immune suppression.

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