The Neurobiology, Physiology, and Psychology of Pain

초록

Pain perception serves to protect living organism against an actual or potential tissue damage. Glutamatergic signaling of nervous system plays a crucial role in initiating and maintaining pain. It is important to note that the glutamatergic signaling in peripheral nervous system (PNS) is responsible for the first phase of pain processing. Recent animal studies support that some types of glutamate receptors such as NMDA receptor and group I metabotropic glutamate receptors (mGluRs) in cell bodies and primary afferent fibers of PNS can potentiate the nociceptive processing. However, much interest was less present in the role of peripheral group III mGluRs for regulating pain. Therefore, the present review will focus on peripheral group III mGluRs of PNS that can offer a better understanding of inhibitory role and therapeutic potential in pain processing.

제목
The Neurobiology, Physiology, and Psychology of Pain
저자
Park, Eui Ho; Han, Hee Chul
DOI
10.1016/b978-0-12-820589-1.00021-x
발행일
2021-11
ISBN
9780128205891