Evaluation of maternal rhesus blood type as a risk factor in adverse pregnancy outcomes in Korea: a nationwide health insurance database study

초록

ObjectivesThe current study aimed to investigate whether pregnancy outcomes are affected by maternal rhesus (Rh) status bycomparing the primigravida pregnancy outcomes of Rh-negative women with those of Rh-positive women. MethodsThe study data were collected from the Korea National Health Insurance Claims Database and the National HealthScreening Program for Infants and Children. In total, 1,664,882 primigravida women who gave birth between January1, 2007 and December 31, 2014, were enrolled in this study. As the risk and severity of sensitization response increaseswith each subsequent pregnancy, only primigravida women were enrolled. The patients were divided into 2 groupsaccording to Rh status, and the pregnancy outcomes were compared. ResultsIn total, 1,661,320 women in the Rh-positive group and 3,290 in the Rh-negative group were assessed. With regardto adverse pregnancy outcomes, there was no statistically significant difference between the 2 groups in terms ofthe prevalence of preeclampsia, postpartum hemorrhage, abruptio placenta, placenta previa, and uterine arteryembolization. A univariate analysis revealed that none of the adverse pregnancy outcomes were significantlycorrelated to Rh status (preeclampsia: odds ratio [OR], 1.00, 95% confidence interval [CI], 0.81–1.23; postpartumhemorrhage: OR, 1.10, 95% CI, 0.98–1.24; abruptio placenta: OR, 0.80, 95% CI, 0.46–1.37; and placenta previa: OR, 1.08,95% CI, 0.78–1.42). The adjusted ORs of postpartum hemorrhage and preterm birth did not significantly differ. ConclusionMaternal Rh status is not associated with adverse outcomes in primigravida women.

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