Characteristics and clinical outcomes of patients with Acinetobacter baumannii associated hospital-acquired pneumonia in Korea

초록

Background and Aims Hospital-acquired pneumonia(HAP) is significant public health issue in the world, and most common pathogen in Korea was Acinetobacter baumannii recently. However we have still not many information about this. The aim of this study was to determine the characteristics and outcomes of patients with Acinetobacter baumannii associated HAP. Methods This study is a multicenter retrospective cohort study of 16 participating hospitals in South Korea. Patients with hospital acquired pneumonia who confirmed as Acinetobacter baumannii infection were included. Results A total of 147 patients were included in this study.Median age was 72 (range from 63 to 79) years, and 106 patients (72.1%) were male. The median period from admission to HAP onset is 11 (range 7 to 18) days, and 41 (78.8%) of them were diagnosed in ICU. Artificial airway was applied in 73 patients (49.7%), and 63 patients of them had E-tube. The median antibiotics using period was 16 (range from 9 to 28) days, and 46.9% of them were used Expended-spectrum penicillin/beta-lactamase inhibitor asinitial line antibiotics. Acinetobacter baumannii was grow thin respiratory tract culture in 98% of patients, 61.2% of patients were met microbiological eradication, and 54.4% of patients were achieved clinically cure. Conclusion In this study, Acinetobacter baumannii associated HAP group shows high mortality. The rate of microbiological eradication is similar to other pathogens. Acknowledgment This research was supported by a fund(2020-ER7201-02) by Research of Korea Centers for DiseaseControl and Prevention Agency.