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A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing
- Cho, Seungchan;
- Allison, Jon C.;
- Park, Kkothanahreum;
- No, Jin Sun;
- Lee, Seung-Ho;
- ... Song, Jin-Won;
- 외 5명
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3초록
An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. The patient had a fever, maculopapular rash, and an eschar. The full-length sequence of Orientia tsutsugamushi 56-kDa type-specific antigen (TSA) gene was obtained from eschar tissue by multiplex PCR-based Next Generation Sequencing for genetic identification. Based on the 56-kDa TSA gene, the O. tsutsugamushi aligned most closely with the Boryong strain.
키워드
Orientia tsutsugamushi; scrub typhus; genetic identification; target enrichment next-generation sequencing
- 제목
- A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing
- 저자
- Cho, Seungchan; Allison, Jon C.; Park, Kkothanahreum; No, Jin Sun; Lee, Seung-Ho; Park, Kyungmin; Kim, Jongwoo; Klein, Terry A.; Kim, Heung-Chul; Kim, Won-Keun; Song, Jin-Won
- 발행일
- 2021-04
- 유형
- Article
- 저널명
- Pathogens
- 권
- 10
- 호
- 4
- 언어
- ENG
- 출판사
- MDPI AG
- 발행국가
- 스위스
- ISSN
- P 2076-0817