한국 HIV/AIDS 코호트 연구의 과거, 현재, 그리고 미래

초록

Objectives: The Korea human immunodeficiency virus/acquired immunodeficiency syndrome, (HIV/AIDS) Cohort Study, initiated in 2006, has been performed to systematically analyze the natural history, treatment responses, complications, drug resistance, and psychosocial factors among people living with HIV (PLHIV) to provide an evidence-based description of disease progression and guidance for disease management. Methods: Since inception of the study in 2006, 21 hospitals have participated, with 15 hospitals actively involved as of 2025. A single epidemiological data center continuously from the early stages of the research, responsible for standardized data collection, quality management, epidemiological consultation, and statistical support. The study includes research on rapid treatment initiation, immune recovery, transmission routes, and non-infectious complications. Results: This research has contributed to improving the survival rate and quality of life among PLHIV by systematically analyzing various factors. Introduction of pre-exposure prophylaxis (PrEP), development of mathematical models to guide policy formulation, and establishment of a high-quality standardized data management system also provide a crucial foundation for future HIV research and policy advancement. Conclusions: Through national big data linkage and sharing, this study is expected to enhance domestic and international research activities.

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