Morphine, Codeine 및 Mephedrine의 진통효과 및 물질대사에 미치는 Iproniazide의 영향

초록

Numerous authors have reported that iproniazid(1-isonicotinyl-2-isopropyl hydrazide), a potent amine oxidase inhibitor, potentiates the effects of various drugs. In order to investigate the influence of iproniazid on the analgesic and metabolic effects of morphine, codeine and meperidine, following experimental studies have been carried out. The analgesic effects were investigated utilizing the hot plate reaction time test in mice, the metabolic effects were investigated measuring the changes of blood sugar content and serum transaminase activities(S-GOT, S-GPT) in rabbits. The animals were pretreated with iproniazid 20 hours prior to experimental study. The results obtained were follows; 1. Analgesic effects of morphine and codeine were markedly increased by pretreatment of iproniazid. 2. Blood sugar levels were markedly decreased by pretreatment of iproniazid alone. 3. The hyperglycemic effects of morphine, codeine and meperidine were suppressed by the pretreatment of iproniazid. 4. Iproniazid suppressed the serum transaminase activities in rabbits. 5. The increased serum transaminase activities induced by morphine, codeine and meperidine were suppressed by the pretreatment of iproniazid. 6. The synergistic effect of iproniazid on the analgesic effects of morphine, codeine and meperidine does not seem to be directly related transaminase activities.