Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

초록

in neuropathic rats sensitive to phentolamme (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha(1)-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha(2)-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia. (c) 2005 Elsevier B.V All rights reserved.

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