The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

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초록

We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model. (C) 2009 Published by Elsevier Ltd.

키워드

Febrile neutropenia; Prognosis; Hematologic malignancy; Albumin; Bicarbonate; C-reactive protein; C-REACTIVE PROTEIN; NON-HODGKINS-LYMPHOMA; CANCER-PATIENTS; MULTINATIONAL-ASSOCIATION; SUPPORTIVE-CARE; PROGNOSTIC SCORE; INFECTION; MORTALITY; THERAPY; NEPHROTOXICITY
제목
The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease
저자
Park, Yong; Kim, Dae Sik; Park, Seh Jong; Seo, Hee Yun; Lee, Se Ryeon; Sung, Hwa Jung; Park, Kyong Hwa; Choi, In Keun; Kim, Seok Jin; Oh, Sang Cheul; Seo, Jae Hong; Choi, Chul Won; Kim, Byung Soo; Shin, Sang Won; Kim, Yeul Hong; Kim, Jun Suk
DOI
10.1016/j.leukres.2009.08.024
발행일
2010-03
유형
Article
저널명
Leukemia Research
권
34
호
3
페이지
294 ~ 300