Handbook of Nutrition, Diet, and Epigenetics

초록

Vitamin C (L-ascorbic acid) is an essential, water-soluble micronutrient that exists predominantly as the ascorbate anion under physiological pH conditions and has been implicated in several processes of reproduction of reproductive organ cells. Several studies described the regulatory roles of vitamin C in various cellular developmental processes, via microRNA mechanism, using in vivo and in vitro animal models. To date, some specific microRNAs have been regarded as candidates that have regulatory roles in vitamin C metabolism. Many questions should be further investigated, such as the following: whether and how vitamin C directly regulates epigenetic modifiers, whether vitamin C regulates gene and miRNA promoters through specific signaling pathways, and whether vitamin C-induced DNA demethylation occurs. ? Springer Nature Switzerland AG 2019. All rights reserved.