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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
- Hu, Xiaoxia;
- Chen, Haiying;
- Jin, Meishan;
- Wang, Xianfu;
- Lee, Jiyun;
- 외 4명
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18초록
Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11; 19)(q11; q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
키워드
Undifferentiated embryonal sarcoma of the liver (UESL); Cytogenetic anomalies; FISH; aCGH; TP53 mutation; COMPARATIVE GENOMIC HYBRIDIZATION; MESENCHYMAL HAMARTOMA; CARCINOMA; TUMOR; AMPLIFICATIONS; CHILDHOOD; MUTATION; REVEALS; COMPLEX; GENE
- 제목
- Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
- 저자
- Hu, Xiaoxia; Chen, Haiying; Jin, Meishan; Wang, Xianfu; Lee, Jiyun; Xu, Weihong; Zhang, Rui; Li, Shibo; Niu, Junqi
- 발행일
- 2012-05-03
- 유형
- Review
- 권
- 5
- 언어
- ENG
- 출판사
- BioMed Central
- 발행국가
- 영국
- ISSN
- P 1755-8166