Etretinate에 의해 유발되는 마우스 배자의 심혈관 기형

초록

Purpose : Etretinate(Tigason? is an aromatic retinoid currently in therapeutic use for psoriasis but studies have shown that it is a potent teratogen in human and in experimental animal. So we carried this study to observe teratogenic effects of etretinate and to search a possibility of etretinate for using as an experimental model to induce cardiovascular malformation. Methods : In order to determine the effect to etretinate on embryonic cardiovascular system, pregnant ICR mice were given intragastrically single doses of 50mg/kg or 100mg/kg of etretinate at day 8,9 or 10 of gestation. Results : All of the 172 treated surviving fetuses, showed extracardiac malformation. Extrecardiac malformations induced were largely craniofacial, limb, tail and thymic defects. Of the 172 treated surviving fetuses, 53(31%) showed cardiovascular anomalis. The highest cardiovascular malformation was induced by administration of 100mg/kg at day 8 of gestation(35/50, 70%), and the most common cardiovascular malformation was transposition of great arteries in the same group.(23/50, 46%) Conclusion : The results indicate that etretinate has a teratogenic effect on developing cardiovascular system and the type and incidence of cardiovascular abnormalities are largely dose and stage dependent.

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