신티그램의 전산화에 의한 간질환의 진단에 관한 연구

초록

Whereas conventional scintigraphic liver imaging have been found to be sensitive in the detection of various hepatic diseases, their detection has been remained a significant limitation of the examination. To evaluate the conventional hepatic scintigraphy of various hepatic diseases, we have devised a computer method that compares liver activity to splenic activity and noticed a acquisition time of the hot pixel as a quantitative assessment, and also determined normal ranges. The results are as follows; 1. Age distribution of various hepatic disease was the most frequent in 6th decade. Studied groups are 22 cases of normal subject, and proven hepatocellular diseases including 62 cases of hepatitis, 51 cases of liver cirrhosis, 18 cases of hepatoma and 8 cases of liver metastasis. 2. In normal subjects, liver to spleen uptake ratio was 61.8±16.9 and acquisition time of hot pixel was 13.0±3.5 second. 3. In hepatitis, liver to spleen uptake ratio (19.5±8.8, p < 0.01) was lower than normal group and slightly delayed acquisition time of hot pixel (26.7±8.9 sec.). 4. In liver cirrhosis, liver to spleen uptake ratio was markedly lowered than normal group (5.0±2.9, p < 0.01) and the most delayed acquisition time of hot pixel among the disease groups (35.8±12.2 sec.). 5. In hepatoma, considerably low liver to spleen uptake ratio (10.4±4.6, p < 0.0l ) and delayed acquisition time of hot pixel than normal group (30.3±8.9 sec.). 6. In hepatic metastasis, liver to spleen uptake ratio (25.3±7.6, p < 0.01) was not significantly altered and acquisition time of hot pixel is similar to normal group (13.4±3.6 sec.).