자궁경부암 환자에서 종양표지물질 CYFRA 21 - 1 의 분석

초록

Objective: CYFRA 21-1 is known to be a cytokeratin 19 fragment and elevated levels of CYFRA 21-1 have been detected in a large number of patients with non-small cell carcinoma of lung, particularly squamous cell carcinoma. The objective of our study were to evaluate the possibility of tumor marker of cervical cancer and to compare serum CYFRA 21-1 with serum SCC in patients with cervical cancer.Materials and methods: From February 1998 to January 1999, serum level of CYFRA 21-1 and SCC were measured in 46 patients with CIN, CIS, carcinoma of cervix before initial treatment. and 21 normal control cases. Results: Using 2.0 ng/ml as cut-off value, elevated CYFRA 21-1 levels were found in 4.8% of control cases, 25% of patients with CIN, 14.3% of patients with CIS, and 41.6% of patients with cervical cancer. Sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of serum CYFRA 21-1 were 41.7%, 95.2%, 90.9% and 58.8%, respectively. The sensitivity was 20.8% for SCC. The mean concentrations of SCC and CYFRA 21-1 were not correlated to FIGO stages and pathologic types. Conclusion: Serum CYFRA 21-1 was more sensitive than serum SCC for both early and advanced carcinoma of the cervix in our study. CYFRA 21-1 may be of significance as an additional marker in the management of patients with cervical cancer, but further investigation is needed.

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