Circadian gene variations are associated with obsessive-compulsive behaviors in a young healthy korean population

초록

Objective: The aim of this study is to evaluate the association between obsessive-compulsive behaviors and variations of circadian genes. Methods: We evaluated whether 6 polymorphisms in 5 circadian genes CLOCK, ARNTL, NPAS2, PER2, and PER3 were associated with obsessive behaviors in a Korean population. In all, 292 healthy subjects were genotyped for 6 circadian gene variants. Obsessive-compulsive behaviors were assessed with the Korean version of Maudsley Obsessive-Compulsive Inventory (MOCI). Results: ARNTL rs2'8749 polymorphism was significantly associated with obsessive-compulsive behaviors in dominant model. PER3 rs57875989 polymorphism and obsessivecompulsive behaviors showed significant association in recessive and genotypic model. Checking and cleaning subscales of MOCI showed statistically significant difference in ARNTL genotypes. Conclusion: The findings of this study support that circadian rhythm may influence obsessive- compulsive behaviors. Further studies are needed to explain the link between the circadian rhythm and obsessive-compulsive behavior. © 2019 Korean Academy of Sleep Medicine.

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