유창성 실어증 환자의 단어 명명 관련 ERP 소견과 뇌 병변과의 관계

초록

The present study aims to reveal the relationship between brain lesion and its ERP signature by aphasic patients. Compared to ERP activation of normal controls divided by two groups with age, ERPs specific to anomic and Wernicke's aphasia were investigated whether the reading ERPs patterns between them were same or not. During word reading ERPs results were observed to be same between two control groups but its amplitudes and latencies of common component consisted of P200, N400 and P600 showing age effect. These differences ascertained that with age, their components' amplitudes and latencies were smaller and later response in favor of speed of processing of Salthouse (1996). The next comparison between Anomic aphasics and normal controls balanced against age were conducted. Their ERPs results were similar on N400 except for the other components such as P200 and P600. Another group of Wernicke's aphasics found no components during epochs observed in Anomic aphaics or normal controls. These characteristics of ERPs were likely to suggest that regarding the relationship between brain lesion and its electrophysiological indexes basal ganglia defect common to Anomic aphasics are linked to the decreasing of phonological encoding process and temporo-parietal lesion to the deficit or lowering of all processing stage. Future study will be more to focus on the comparison of topographical activation pattern with regard to fine-grained classified aphasics through multi-channel EEG.

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