추간판 탈출증의 추간판 조직에서 관찰되는 신생 혈관 및 bFGF 발현과 임상 증상과의 관련성

초록

STUDY DESIGN: To study the correlation between the clinical outcomes and neovascularization and bFGF expression in the herniated disc tissues. OBJECTIVES: To study the difference of neovascularization and bFGF expression according to the types of disc herniation, and to study the correlation between the duration of radiculopathy, post-operative results and neovascularization and bFGF expression in the herniated disc tissues. SUMMARY OF LITERATURE REVIEW: Neovascularization has been found in herniated disc tissue. bFGF(basic Fibroblast Growth Factor) in the intervertebral disc has been implicated in the pathogenesis of injury and repair associated with granulation and neovascularization. There is no information on the relationship between clinical outcome and the neovascularization and bFGF expression in the herniated disc tissue. MATERIALS AND METHODS: Among 112 specimens, there are 48 cases in protrusion, 36 in extrusion and 28 in sequestration. Hematoxylin-eosin stain and immunochemical stain with CD 31 and bFGF were used. For the evaluation of post-operative results, Kirkaldy-Willis method was used. The results were analyzed with Chisquare test and t-test. RESULTS: Statistically there is no correlation between the types of disc herniation, duration of radiculopathy and post-operative outcomes and neovascularization and bFGF expression. CONCLUSIONS: The neovascularization and bFGF expression in herniated disc tissue are correlated with the injury of disc tissue. There are no correlation with the clinical outcomes and neovascularization and bFGF expression in herniated disc tissues.

키워드