N형 전압의존성 칼슘채널 α1 subunit 유전자의 염색체상에서의 위치와 신경계에서의 분포

초록

Voltage dependent calcium channels mediate wide variety of physiological functions including neurotransmitter release, neurite outgrowth, and gene expression in neurons. ω-Conotoxin-sensitive N-type calcium channels are exclusively expressed in nervous system and involved in the control of neurotransmitter release from neurons. In this experiment, I have investigated human chromosomal location and rat neuronal distribution of N-type voltage dependent calcium channel α1 subunit (α1B). I have localized human α1B subunit gene to the long arm of chromosome 9 (9q34) by fluorescent in situ hybridization. The distribution of rat α1B subunit mRNA has been examined in the rat brain by in situ hybridization histochemistry and high level of α1B subunit mRNA has been observed in olfactory bulb, anterior olfactory nucleus, cerebral cortex, piriform cortex, hippocampus, dentate gyrus, parabrachial nucleus, and cerebellum and low level of expression was also found in other areas of rat brain.

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