유세포계측검색에 의한 비·부비동 도립유두종의 핵 DNA량 분석

초록

Inverted papillomas of the nose and paranasal sinuses are multifocal tumors of unknown etiology that have a high recurrence rate and invasive growth pattern. Inverted papillomas tend to transform into malignant tumor. Early diagnosis and aggressive surgical therapy are thus essential. Flow cytometric analysis of nuclear DNA content from paraffin-embedded specimens has been introduced as an important diagnostic and prognostic methods in clinical and investigative oncology. We analysed nuclear DNA content in order to detect possible alternations in DNA histogram as a prognostic indicator of the malignant transformation of the inverted papilloma. The results were as follows: 1) Normal nasal mucosa and inverted papilloma showed diploidy, but squamous cell carcimoma of the maxillary sinus showed aneuploidy. 2)Mean values of S+G₂M% in normal nasal epithelia, inverted papilloma, and squamous cell carcinoma were 10.2%, 19.2% and 29.4%, respectively and the differences between them were statically significant. It was suggested that the presence of aneuploidy and increased S+G₂M% might be good prognostic indicators of malignant change of inverted papilloma.

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