상세 보기
GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents
- Kim J.I.;
- Park S.;
- Lee I.;
- Lee S.;
- Shin S.;
- ... Park M.-S.;
- 외 7명
Citations
WEB OF SCIENCE
14Citations
SCOPUS
17초록
To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.
키워드
antiviral drug; green fluorescent protein; influenza; antivirus agent; enzyme inhibitor; green fluorescent protein; animal; article; Bagg albino mouse; drug effect; drug screening; female; genetics; human; influenza; Influenza virus A; Influenza virus A H1N1; metabolism; methodology; mouse; pathogenicity; physiology; virology; virulence; Animals; Antiviral Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mice; Mice, Inbred BALB C; Virulence; Influenza A virus; Mus; Orthomyxoviridae
- 제목
- GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents
- 저자
- Kim J.I.; Park S.; Lee I.; Lee S.; Shin S.; Won Y.; Hwang M.-W.; Bae J.-Y.; Heo J.; Hyun H.-E.; Jun H.; Lim S.S.; Park M.-S.
- 발행일
- 2012-04
- 유형
- Article
- 권
- 50
- 호
- 2
- 페이지
- 359 ~ 362
- 언어
- ENG
- 출판사
- 한국미생물학회
- 발행국가
- 대한민국
- 분량
- 4 페이지
- ISSN
- E 1976-3794
P 1225-8873