허혈성 뇌졸중환자에서 Apolipoprotein E의 다형성

초록

BACKGROUND The possible role of apolipoprotein E (APOE for gene, apoE for protein) allele in atherosclerotic diseases is not clearly understood. For the putative role of APOE genotypes, we examined APOE polymorphism among patients with stroke. METHODS A total of 202 ischemic stroke patients were involved in this study. The genotype DNA was isolated from whole blood and the APOE alleles were determined by polynicrase chain reaction. RESULTS The genotype of APOE ε3/3 was the most common allele in the stroke group and the control group. The frequencies of APOE ε2, ε3, ε4 allele in stroke group were 0.052, 0.851, and 0.097, respectively. There was no significant difference in APOE genotypes between the stroke group and the control group. No significant associations lions were found for the APOE genotypes and the serum lipid profiles. CONCLUSION These findings suggest that APOE was not related to the stroke.

키워드